ABSTRACT
MeAN administration (40mg/kg body wt/day (i.e. 1/5 of LD50) resulted in increased levels of lipid peroxidation products, conjugated dienes and lipofuscin-like substances in rat liver. Significant decrease in GSH and a decreased activity of hepatic SOD, CAT and GPx were observed. There was also an increase in glutathione S-transferase and G6PD activities, decreased plasma ceruloplasmin and vitamin C implying oxidative stress caused by MeAN.
Subject(s)
Animals , Antioxidants/metabolism , Glutathione/metabolism , Lipid Peroxidation/drug effects , Lipofuscin/metabolism , Liver/drug effects , Male , Methacrylates/toxicity , Nitriles/toxicity , Oxidative Stress/drug effects , Rats , Rats, WistarABSTRACT
Effect of acrolein (2.5 mg/kg body wt/day) on the rat liver antioxidant defense system was investigated. Following 45 days of acrolein exposure, the levels of glutathione, ascorbic acid and the activity of catalase were decreased whereas the activities of superoxide dismutase and glutathione peroxidase were increased. The increase in the level of thiobarbituric acid reactive substances in the acrolein treated rats showed oxidative damage. The results indicate that acrolein interferes with the antioxidant defense system of rat liver.
Subject(s)
Acrolein/pharmacology , Animals , Antioxidants/metabolism , Liver/drug effects , Male , RatsABSTRACT
Administration of amiodarone (AD) to rats leads to marked damage to liver, as evidenced by pathological changes and significant increases in activities of serum marker enzymes and levels of lipids like cholesterol and phospholipids with no alteration in the triglyceride levels. The risk factor, that is the total cholesterol/HDL cholesterol ratio, exhibited increase in the experimental animals, indicating that amiodarone treatment may lead to the development of coronary heart disease.
Subject(s)
Alanine Transaminase/metabolism , Alkaline Phosphatase/metabolism , Amiodarone/pharmacology , Animals , Aspartate Aminotransferases/metabolism , Cholesterol/blood , Isoenzymes/metabolism , L-Lactate Dehydrogenase/metabolism , Lipid Metabolism , Lipids/blood , Liver/drug effects , Male , Phospholipids/metabolism , Rats , Rats, Wistar , Triglycerides/metabolismABSTRACT
Administration of single dose (175 mg/kg body wt) of amiodarone dissolved in water through gavage for 3 weeks damaged the lung and changed the content of lung lavage. Activities of bronchoalveolar lavage (BAL) angiotensin converting enzyme (ACE) and lactate dehydrogenase (LDH) increased significantly. Also, the protein and lactate content of the lavage fluid increased significantly over the control. The drug also produced marked changes in morphology of the lung of experimental animals.